Hypertonic Saline for Hyponatremia

Metadata

• Author: AJKD Blog
• Full Title: Hypertonic Saline for Hyponatremia
• Category: #articles
• URL: https://ajkdblog.org/2022/10/26/hypertonic-saline-for-hyponatremia/

Highlights

• This misconception originated from a 1979 study comparing peripheral venous infusions of amino acids for parenteral nutrition to nonnitrogen solutions (e.g., 5% dextrose in 0.9% saline). Amino acid solutions with osmolarity  >600 mOsm/L infused for 35.2±19.9 hours had twice the risk for phlebitis associated with nonnitrogen solutions.   These findings were conflated to apply to 3% saline (osmolarity 1027 mOsm/L) which was not studied (View Highlight)